1 edition of Toxicity of 1,1-dichloroethylene (vinylidene chloride) to aquatic organisms found in the catalog.
Toxicity of 1,1-dichloroethylene (vinylidene chloride) to aquatic organisms
by Environmental Research Laboratory-Duluth, Office of Research and Development, U.S. Environmental Protection Agency, Available to the public through the National Technical Information Service in Duluth, Springfield, Va
Written in English
|Statement||by D.C. Dill ... [et al.]|
|Series||Research reporting series -- EPA-600/3-80-057|
|Contributions||Dill, D. C, Environmental Research Laboratory (Duluth, Minn.), Dow Chemical Company|
|The Physical Object|
|Pagination||vii, 18 p. :|
|Number of Pages||18|
Vinylidene chloride (VDC, 1,1-dichloroethylene) is a volatile chemical that has been used as a chemical intermediate in the production of 1,1,1-trichloroethane and widely used as a . Display Name: 1,1-dichloroethylene EC Number: EC Name: 1,1-dichloroethylene CAS Number: Molecular formula: C2H2Cl2 IUPAC Name: 1,1-dichloroethene.
The same laboratory con- firmed that exposure to 1,1-dichloroethylene at 10 to 40 ppm ( ma/ m3) in air (6 hours/day, 5 day/week for 18 months) was not carcinogenic to Sprague-Dawley rats (Rampy et al., ~. 1,1-Dichloroethylene monomer was dissolved in olive oil and given orally to 24 pregnant female BD IV rats at a dose of mg/kg on. The Safe Drinking Water and Toxic Enforcement Act. The Proposition 65 List. The current Proposition 65 list is dated Janu Ethylene, 1,1-dichloro-; Sconatex; Vinylidene chloride; 1,1-Dichloroethene; 1,1-Dichloroethylene; CH2=CCl2; Chlorure de vinylidene; 1,1-DCE; NCI-C; Rcra waste number U; VDC; Vinylidine chloride.
Physiologically based pharmacokinetic (PBPK) modeling and gas uptake experiments were utilized to verify the competitive inhibition mechanism of interaction between trichloroethylene (TCE) and 1,1-dichloroethylene (DCE) and to investigate the presence of an interaction threshold between the two chemicals. Initially, gas uptake experiments were Cited by: - LGXVIGDEPROXKC-UHFFFAOYSA-N - 1,1-Dichloroethylene - Similar structures search, synonyms, formulas, resource links, and other chemical information.
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Dawson et al. () evaluated the ability of 1,1-DCE administered in drinking water at ppm or ppm to female Sprague-Dawley rats (body weight g) to induce fetal cardiac changes.
Rats were administered ppm 1,1-DCE for 61 days before mating or for 48 days before mating and for 20 days during gestation. A number of studies in animals have investigated the short-term and subchronic toxicity of cis- or trans-1,2-DCE by either the oral or inhalation route. Presented below are summaries of these investigations.
No chronic studies for cis- or trans-1,2 File Size: 1MB. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here.
Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is also presented, but is described in less. 1,1-Dichloroethylene (DCE), also known as vinylidene chloride, DC, 1,1-DCE, and 1,1-dichloroethene, has been used as a chemical intermediate and in the manufacture of poly vinylidene copolymers.
Polymers of DCE and vinyl chloride are used as food wrap (CEH ). DCE is Toxicity of 1,1-dichloroethylene book synthetic chemical with no known natural sources (USEPA ).Cited by: 5. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products.
To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above. Cancer Information: Dichloroethylene, 1,1- 1,1,2,2-Tetrachloroethane. 1,1-dichloroethylene metabolites in the lungs of adult and weanling male and female mice: correlation with severities of bronchiolar cytotoxicity.
J Pharmacol Exptl TherapFile Size: KB. Basis for revised IDLH: The revised IDLH for 1,1-dichloroethane is 3, ppm based on acute inhalation toxicity data in animals [Carpenter et al.
; Mueller ]. Carpenter CP, Smyth HF Jr, Pozzani UC. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds. 1,1-Dichloroethylene (1,1-DCE) is a synthetic liquid also called 1,1-dichloroethene.
1,1-DCE has a mild, sweet smell similar to chloroform. Nearly all the 1,1-DCE industry uses goes to make solvents/degreasers, adhesives, synthetic fibers, refrigerants, food packaging, and coating resins. RISK: Information regarding the potential of 1,1-dichloroethane to cause toxic effects in humans is limited.
Irregular heartbeat, intoxication, dizziness, nausea and vomiting have been observed with the use of 1,1-dichloroethane as an anesthetic. Also known as: 1,1-Dichloroethene, 1,1-DCE, Vinylidene chloride Chemical reference number (CAS): 1,1-Dichloroethylene (1,1-DCE) is a man-made substance used to make fire retardant fibers and polyethylene food wraps.
It is a clear, colorless, flammable liquid with a mild, sweet smell. Dichloroethylene evaporates quickly at room temperature and can pollute the air. Exposure of fasted male rats for 4 hr to ppm of 1,1-dichloroethylene (1,1-DCE), which decreases hepatic contents of reduced glutathione (GSH), resulted in severe liver injury by 2 hr as manifested by morphologic and histochemical (i.e., Ca and glucosephosphatase) alterations, elevation of serum alanine-a-ketoglutarate transaminase activity, increases in hepatic contents Cited by: PDF ( K) PDF-Plus ( K) Citing articles; Pulmonary toxicity of 1,1-dichloroethylene: correlation of early changes with covalent bindingCited by: unsymmetrical chlorinated oxiranes such as 1,1-dichloroethylene, 1,1,2-trichloroethylene and monochloroethylene (vinyl chloride).
The carcinogenicity of 1,1-dichloroethylene has primarily been associated with inhalation exposure while that of vinyl chloride,File Size: KB. 1, 1-Dichloroethene is an industrial chemical that is not found naturally in the environment.
It is a colorless liquid with a mild, sweet smell. It is also called vinylidene chloride. 1, 1-Dichloroethene is used to make certain plastics, such as flexible films like food wrap, and in packaging materials.
It is also used to make flame retardant coatings for fiber and carpet backings, and in. Vinylidene Chloride (1,1-Dichloroethylene) Hazard Summary Vinylidene chloride is used as an intermediate in chemical synthesis and to produce polyvinylidene chloride copolymers.
The primary acute (short-term) effects in humans from vinylidene chloride exposure are on. The toxicity of 1,1-DCE was less severe in female rats and there was no significant effect of rat size on 1,1-DCE toxicity in females. In rats of both sexes the dose dependence of the hepatotoxic response was complex, possessing a threshold level, a region of precipitous increase, and a plateau, where larger doses were ineffective in increasing by: R – This substance was identified as toxic to reproduction 1,1-Dichloroethylene (stabilized with MEHQ) (in cylinder without valve) [To use this product charged in cylinder, a valve is required which is sold separately (Product Code:V)] C&L Inventory.
CV2. Registration dossier. Fig. 1: Pathways for 1,1-dichloroethene metabolism and toxicity (see text for details). The primary metabolites of 1,1-DCE formed in rat hepatic microsomal incubations are DCE-epoxide, 2,2-dichloroacetaldehyde, and 2-chloroacetyl chloride (Costa & Ivanetich,; Liebler et al.,).
The way 1,1-dichloroethene and its breakdown products leave the body depends on the amount of 1,1-dichloroethene that enters the body. Low or moderate levels breathed in ( ppm) or taken by mouth (up to 50 milligrams per kilogram of body weight) leave the body mainly as breakdown products in the urine.
Additional Physical Format: Online version: Toxicity of 1,1-dichloroethylene (vinylidene chloride) to aquatic organisms.
Duluth: Environmental Research Laboratory-Duluth, Office of Research and Development, U.S. Environmental Protection Agency ; Springfield, Va.: Available to the public through the National Technical Information Service. The human epidemiological results on the carcinogenicity of 1,1-DCE are too limited to draw useful conclusions.
EPA concludes that the results of kidney tumors in one sex and one exposure in a single species of rodents are too limited to support an exposure-response assessment.1,1-Dichloroethylene (DCE) exposure to mice elicits lung toxicity that selectively targets bronchiolar Clara cells.
The toxicity is mediated by DCE metabolites formed via cytochrome P : Poh-Gek Forkert.Effect ofAOAA on the renal toxicity of DCE Group 1: AOAA in distilled water (3 X mg/kg) was administered by oral gavage 30 min prior to and 10 min and 5 h following oral admin- istration of DCE.
Group 2: mice were dosed as mice of Group 1 except that the distilled water served as a substitute for by: 9.